課程資訊
課程名稱
基因體研究特論
Special Topics in Genomic Studies 
開課學期
110-1 
授課對象
公共衛生學院  流行病學與預防醫學研究所  
授課教師
郭柏秀 
課號
EPM7181 
課程識別碼
849 M0750 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期三3,4(10:20~12:10) 
上課地點
公衛208 
備註
與盧子彬、馮嬿臻合授
限碩士班以上
總人數上限:15人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1101EPM7181_ 
課程簡介影片
 
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課程概述

The major goal of this course is to learn the concepts, new methods and findings of a wide-range of topics in genomic studies through reading and discussion of original articles. Selected articles of each topic have a major theme and involved various issues commonly encountered in genomic studies. Course will begin with an introductory lecture to point out important issues. Students are expected to read assigned articles in advance and discuss the designated questions during class. We’ll cover topics related to a) Study design, data analysis and integration; b) Assessment of human genome variation and regulation; c) Using genomic information in medicine and public health; and d) Ethical issues in using genomic data. 

課程目標
1. To learn the concepts, new methods and findings of a wide-range of topics in genomic studies.
2. To learn how to read critically original articles in genomic studies.
 
課程要求
[具備基礎遺傳學知識,或修習過遺傳流行病學原理、其他授課教師認可之遺傳相關課程]
Class participation: including presentation and discussion.
Assignments: written discussion about the designated questions listed in each session.
Final report: choose a topic and describe concisely the design, main findings, unsolved problems, and future directions of studies in the field.
 
預期每週課後學習時數
 
Office Hours
另約時間 
指定閱讀
待補 
參考書目
Human Genome Epidemiology, 2nd Edition

Building the evidence for using genetic information to improve health and
prevent disease.

Edited by
Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis,
and Julian Little 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Class participation 
45% 
 
2. 
Class assignments 
25% 
 
3. 
Final report 
30% 
 
 
課程進度
週次
日期
單元主題
第1週
9/22  Module I : GWAS in complex traits 郭柏秀 
第2週
9/29  Module I : Understanding polygenic risk score (PRS) 郭柏秀 
第3週
10/6  Module I : Pharmacogenomics in real world 郭柏秀 
第4週
10/13  Module I : Case study (presentation) 郭柏秀 
第5週
10/20  Module II : Introduction of rare variants 盧子彬 
第6週
10/27  Module II : The roles of non-coding variants 馮嬿臻 
第7週
11/3  Module II : Applications of rare variants studies 馮嬿臻 
第8週
11/10  Module II : Case study (presentation) 郭柏秀 
第9週
11/17  Module III : Introduction of metagenomics 郭柏秀 
第10週
11/24  Module III : Applications of metagenomics studies 盧子彬 
第11週
12/1  Module III : Case study (presentation) 郭柏秀 
第12週
12/8  Module IV : Introduction of Biobanks 李德章 
第13週
12/15  Module IV : Applications of biobank studies 馮嬿臻 
第14週
12/22  Module IV : Case study (presentation) 郭柏秀 
第15週
12/29  Final report 郭柏秀 
第16週
1/5  Final report 郭柏秀